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1. Skin tone&Skin texture improvement: With improved moisture balance, Increases the thickness and density of the dermis, Helps improve pigmentation, improve skin tone
2. Improve skin problems: Increase fibroblast function
3. Shrink Pores: Gaping pores from inside the skinPore tightening effect
4. Moisturizing the skin: Skin Affinity PolymerApply hyaluronic acid, deep inside the skinPull moisture and give rich moisturizing Offer
UNDERSTANDINGS OF MAIN INGREDIENTS
(Best Anti-aging Booster created by optimized combination with HA, PN & Stemcell Growth Factors)
KEY INGREDIENTS
HA, PN(polynucleotide), GROWTH FACTORS, AMINOACIDS, VITAMINS, ANTIOXIDANT, MINERALS
7 CHARACTERISTICS
1. High Molecular and Maximum Concentration of HA which will be disappear the embossing within 72hrs as Moisturizing Component (140M Da HA,0.5%).
2. Maximum Concentration of PN which is without cloudy suspension and salmon smell for cellular proliferation DNA raw materials(0.3%).
3. Very High Concentration of Growth Factors compare to existing Skin Booster as Stemcell Activator(about 10 to 100times).
4. Enough High Concentration Amino acids as Collagen Raw Material Source.
5. Maximum Concentration of Glutathione without discoloration and odor as Antioxidant and Brightening agent .
6. Enough Concentration of Niacin-amide to inhibit Melanosome transfer from Melanocyte to Keratinocyte as Whitening Component
7.Not included the ” Surfactants”, “Artificial Solvent” ,” Preservative”, “Fragrance”, “Colorant”,” Silicone” and even “Synthetic Peptides”.
8.Does not contain 1) Alanine, which causes tissue irritation, 2)Tyrosine and Phenylalanine, which are raw material of Melanin Pigment.
1. The Concentration of HA which is a beaded Hyaluronic Acid by MDM Tech.® ( Micro Bead Monophasic , Divinyl sulfone multi-crosslink , Multiple Degree Amphiphilic Purification) is 0.6%.

2. Maximum Concentration of PDRN which is without cloudy suspension and salmon smell for cellular proliferation DNA raw materials(0.3%).

3. Very High Concentration of Growth Factors compare to existing Skin Booster as Stemcell Activator(about 10 to 100times).



Laboratory Result of Le Reve HS +








0.31
0.29
0.27
0.25
0.23
0.21
0.19
0.17
0.15
NIH3T3 proliferation for 2 days
Control(D.W)
RegenK booster
Sample
1day(%)
Sample
2day(%)
Control(D.W)
100
107
RegenK booster
104
167
RegenK booster
0.32
0.3
0.28
0.26
0.24
0.22
0.2
Control(D.W)
HaCaT proliferation for 2 days
Sample
1day(%)
Sample
2day(%)
Control(D.W)
100
106
RegenK booster
110
145
SKIN BENEFITS
Stimulate natural skin regeneration and healing at cellular level
Visible Skin Brightening & Glow
Improved Skin Elasticity & Hydration
Unclog Pores and removal of dead cells
Stimulation of Collagen and more even skin tone
Thickening Skin & Decreasing Fine Wrinkles

UNDERSTANDINGS OF MAIN INGREDIENTS
Best Anti-aging Booster created by optimized combination with HA, PN & Stemcell Growth Factors




REGEN HA++ contains 1,400k Da Non-Crosslinked HA 0.5%
(High Molecular Weight, Maximum concentration as Skin Booster), which prevents skin aging by containing HA of sufficient quality to ensure the best water resistance and skin affinity among the skin boosters developed so far.
You can keep your skin moisturizing and elastic.

Polynucleotides (PDRN)
Polynucleotides (PDRN) have become a real sensation in the world of cosmetology.
Polynucleotides are precisely those “bricks” that restore the structure of the skin from the inside, increasing the production of collagen.
Polynucleotides (PDRN)
Polynucleotides (PDRN) have become a real sensation in the world of cosmetology.
Polynucleotides are precisely those “bricks” that restore the structure of the skin from the inside, increasing the production of collagen.
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The action of PDRN on the skin:
stimulate repair processes
• accelerate skin re-epithelization and scarring
• provide fast and harmonious formation of granulation tissue in the wound area
• increase the metabolic activity of cells
• stimulate angiogenesis (restore microcirculation in tissues)
• enhance the moisturizing effect of hyaluronic acid
• reduce the level of pro-inflammatory cytokine TNF-a (decrease in
• inflammatory manifestations of acne) are highly effective traps of free radicals (protect from damage by metabolites, xenobiotics, temperature factors, etc.)
• protect against UVB radiation and prevent the development of pigmentations
HYALURONIC ACID: A POPULAR ANTI-AGING AGENT
Hyaluronic acid (HA) is a disaccharide– a molecule consisting of two sugar molecules (uronic acid and N-acetylglucosamine) that occurs naturally in the body.

It is most prominently found in the eyes, skin and connective tissue. In the skin, HA chains are usually between 1,000 to 10,000 disaccharides long.
This sprawling molecule can attract and hold almost 1000 times its weight in water, helping to keep skin plump and hydrated.
High levels of hyaluronic acid in the skin also encourage collagen production and facilitate nutrient transfer through the skin, helping the skin to heal from damaging ultraviolet radiation exposure.
You can see why it was first targeted as a possible ally in the fight against aging.
STEM CELLS GROWTH FACTORS
Stem cells play a critical role in tissue regeneration and repair, maintenance and turnover and the control of haematopoiesis in the various tissues.
The peptides contained in REGENT HS++ contain only 100% of the stem cell growth factor components existing in the human body, and any synthetic peptides are not added.
The contents are 10 to 100 times higher concentration than skin boosters containing existing stem cell growth factors.
EGF: 1 ppm, a-FGF: 0.1 ppm, b-FGF: 1 ppm, IGF-1: 0.1 ppm,PDGF-a: 1 ppm, PDGF-b1: 0.5 ppm, VEGF: 0.5 ppm, TGF-b1: 0.5ppm,
Interleukin 10: 0.1ppm
These cells have an incredible ability to differentiate into specific cell types like osteoblasts, chondrocytes or myocytes and to develop bone, cartilage or muscle tissues.
Now it is believed that the cells do not differentiate by themselves but rather the secretion of the bioactive (trophic) factors which are responsible for the functional outcome of the tissue.
Stem cells reside in complicated and dynamic three-dimensional (3D) microenvironments in vivo known as stem cell niches.
The niches are composed of extracellular matrix (ECM), soluble and tethered proteins and supporting cells, which have a profound influence on the functionality of the cells, including differentiation and trophic factor release.





REGENT HA++ PROCEDURE
Almost all of customers did not complain of pain during procedure after 9.6% Lidocain Cream apply for 25min and add 10min, total 35min. If we want more anesthesia,
Dr can add Peripheral nerve block ( Supra-Orbital NB, Supra-Trochlear NB, Zygomatic NB
(Infra-Orbital NB), MandibularNB.)Supra-Orbital NB, Supra-Trochlear NB
1) Source(Salmon Sperm) based on the know-how of filler technology development and specialized technology.
2) Maximum concentration without cloudy and smell 0.3%
3) It is composed 4 kinds of Nucleotide ( A C T G ) which can be source to DNA synthesis.





VITAMINS
REGENT HS ++ contains vitamins that improve the basic metabolism of the skin in an optimal concentration, and in particular, NIACINAMIDE, Vit B3, which enhances whitening, antioxidant, and collagen synthesis, is contained in the maximum concentration(200ppm)) that does not cause problems even if it enters the skin directly.

Skin Mechanism of Niacin-amide
1, Niacin-amide collects melanin pigment synthesized in melanocytes and blocks the transfer of “Melanosome”, a non-pocket, to keratinocytes by 35%~68%.
2. Niacin-amide synthesizes collagen by promoting “m-RNA transcription” that synthesizes collagen in the dermal layer.
3. Niacin-amide promotes the proliferation of keratinocytes by activating “mKGF”. It is accompanied by effects such as reducing pores, suppressing sebum
excretion, and relieving acne.

GLUTATHIONE
Glutathione is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine), which work in unison to offer skin-restoring and brightening benefits when used in topical products.

Glutathione can reduce minor skin imperfections and produce an overall brighter complexion while improving uneven skin tone.
It has a beneficial effect for cystic acne or even the occasional breakout. Glutathione injections work by clearing the body of toxins and free radicals that lead to hyperpigmentation, age spots, sun spots, wrinkles, acne, and even melasma.
It also has anti-inflammatory benefits.
REGEN HS++ contains the highest concentration(400ppm/ml) of glutathione that humans cannot detect with the eyes and nose of browning and sulfur odors.
1. In the process of synthesizing melanin in melanocytes, it synthesizes “Pheomelanin”, which is a pink (middle of red and yellow) melanin pigment
instead of black melanin pigment.
2. It is difficult to pass through the cell membrane, but once it passes, it becomes the center of strong antioxidant by “continuously recycling hydrogen”.
3. Combining with lead, which is the main cause of cosmetic poisoning, is discharged and can increase the intensity of tumor treatment by protecting
normal cells during chemotherapy.


Melanin Raw Materials : Tyrosine, Phenylalamine. Tissue Irritation : Alanine. Sulfur Smell: Glutathione, L-Cysteine
Injection pain : Tranexamic Acid.